Direct Handwriting Editing

This publication describes techniques for enabling handwriting and text editing on touch-sensitive surfaces (e.g., touchscreens, touchpads, interactive whiteboards) without the use of a physical or virtual keyboard. These techniques enable users to perform free-form handwriting gestures anywhere on a touch-sensitive surface, and also to perform editing gestures that modify previously created text without a mode change. A computing system (e.g. mobile phone, tablet computer, personal digital assistance, laptop computer, interactive whiteboard) may analyze the shapes of user gestures input at a touch-sensitive surface, as well as the relative positions of these gestures compared to existing displayed text, and determine whether the user intended to edit existing text or instead to write new text. If the system determines that the user intended to edit existing text, the system applies an appropriate editing operation to the text (e.g., text selection, text deletion/replacement, text insertion/movement, text merging, text separation). Otherwise, the computing system interprets the user’s strokes as regular handwriting and interprets the strokes for new text entry using a handwriting recognizer. The techniques described in this publication may provide one or more advantages. For example, the described system does not require the use of a physical or even virtual keyboard. Because the system does not provide a popup virtual interface for text entry or editing operations, the system increases the amount of available screen space for text entry or editing operations. A user can write and/or edit anywhere on the touch-sensitive surface (e.g., directly on target text or at a target location), instead of having to write or edit in a dedicated region of the screen, and the user does not need to move or otherwise manipulate a cursor before performing editing operations. The system is able to create a new text label with a desired size, position, and/or orientation as soon as user finishes writing. In addition, multiple different users may be able to simultaneously enter new text or edit existing text on a large touch-sensitive surface, such as an interactive whiteboard

Cytokines and depression in cancer patients and caregivers.

Objective:A better understanding of the biobehavioral mechanisms underlying depression in cancer is required to translate biomarker findings into clinical interventions. We tested for associations between cytokines and the somatic and psychological symptoms of depression in cancer patients and their healthy caregivers. Patients and methods:The GRID Hamilton Rating Scale for Depression (Ham-D) was administered to 61 cancer patients of mixed type and stage, 26 primary caregivers and 38 healthy controls. Concurrently, blood was drawn for multiplexed plasma assays of 15 cytokines. Multiple linear regression, adjusted for biobehavioral variables, identified cytokine associations with the psychological (Ham-Dep) and somatic (Ham-Som) subfactors of the Ham-D. Results:The Ham-Dep scores of cancer patients were similar to their caregivers, but their Ham-Som scores were significantly higher (twofold, p=0.016). Ham-Som was positively associated with IL-1ra (coefficient: 1.27, p≤0.001) in cancer patients, and negatively associated with IL-2 (coefficient: -0.68, p=0.018) in caregivers. Ham-Dep was negatively associated with IL-4 (coefficient: -0.67, p=0.004) in cancer patients and negatively associated with IL-17 (coefficient: -1.81, p=0.002) in caregivers. Conclusion:The differential severity of somatic symptoms of depression in cancer patients and caregivers and the unique cytokine associations identified with each group suggests the potential for targeted interventions based on phenomenology and biology. The clinical implication is that depressive symptoms in cancer patients can arise from biological stressors, which is an important message to help destigmatize the development of depression in cancer patients

The Dust and Molecular Gas in the Brightest Cluster Galaxy in MACS 1931.8-2635

We present new ALMA observations of the molecular gas and far-infrared continuum around the brightest cluster galaxy (BCG) in the cool-core cluster MACS 1931.8-2635. Our observations reveal $1.9 \pm 0.3 \times 10^{10}$ M$_{\odot}$ of molecular gas, on par with the largest known reservoirs of cold gas in a cluster core. We detect CO(1-0), CO(3-2), and CO(4-3) emission from both diffuse and compact molecular gas components that extend from the BCG center out to $\sim30$ kpc to the northwest, tracing the UV knots and H$\alpha$ filaments observed by HST. Due to the lack of morphological symmetry, we hypothesize that the $\sim300$ km s$^{-1}$ velocity of the CO in the tail is not due to concurrent uplift by AGN jets, rather we may be observing the aftermath of a recent AGN outburst. The CO spectral line energy distribution suggests that molecular gas excitation is influenced by processes related to both star formation and recent AGN feedback. Continuum emission in Bands 6 and 7 arises from dust and is spatially coincident with young stars and nebular emission observed in the UV and optical. We constrain the temperature of several dust clumps to be $\lesssim 10$ K, which is too cold to be directly interacting with the surrounding $\sim 4.8$ keV intracluster medium (ICM). The cold dust population extends beyond the observed CO emission and must either be protected from interacting with the ICM or be surrounded by local volumes of ICM that are several keV colder than observed by Chandra.Comment: Accepted for Publication in ApJ, 19 pages, 11 figures. Minor revisions to the discussion and accompanying figur

Ketones Improves Apolipoprotein E4-Related Memory Deficiency Via Sirtuin 3

Background: Apolipoprotein E4 (ApoE4) is the major genetic risk factor of Alzheimer\u27s disease (AD). ApoE4 carriers have cerebral hypometabolism which is thought as a harbinger of AD. Our previous studies indicated ketones improved mitochondria energy metabolism via sirtuin 3 (Sirt3). However, it is unclear whether ketones upregulate Sirt3 and improve ApoE4-related learning and memory deficits. Results: Ketones improved learning and memory abilities of ApoE4 mice but not ApoE3 mice. Sirt3, synaptic proteins, the NAD+/ NADH ratio, and ATP production were significantly increased in the hippocampus and the cortex from ketone treatment. Methods: Human ApoE3 and ApoE4 transgenic mice (9-month-old) were treated with either ketones or normal saline by daily subcutaneous injections for 3 months (ketones, beta-hydroxybutyrate (BHB): 600 mg/kg/day; acetoacetate (ACA): 150 mg/kg/day). Learning and memory ability of these mice were assessed. Sirt3 protein, synaptic proteins (PSD95, Synaptophysin), the NAD+/ NADH ratio, and ATP levels were measured in the hippocampus and the cortex. Conclusion: Our current studies suggest that ketones improve learning and memory abilities of ApoE4 transgenic mice. Sirt3 may mediate the neuroprotection of ketones by increasing neuronal energy metabolism in ApoE4 transgenic mice. This provides the foundation for Sirt3\u27s potential role in the prevention and treatment of AD

The dark side of the gut: Virome-host interactions in intestinal homeostasis and disease

The diverse enteric viral communities that infect microbes and the animal host collectively constitute the gut virome. Although recent advances in sequencing and analysis of metaviromes have revealed the complexity of the virome and facilitated discovery of new viruses, our understanding of the enteric virome is still incomplete. Recent studies have uncovered how virome-host interactions can contribute to beneficial or detrimental outcomes for the host. Understanding the complex interactions between enteric viruses and the intestinal immune system is a prerequisite for elucidating their role in intestinal diseases. In this review, we provide an overview of the enteric virome composition and summarize recent findings about how enteric viruses are sensed by and, in turn, modulate host immune responses during homeostasis and disease

WIC Participation and Breastfeeding After the 2009 WIC Revision: A Propensity Score Approach

In this study, we examined the association between participation in the Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) and breastfeeding outcomes before and after the 2009 revisions. Four-thousand-three-hundred-and-eight WIC-eligible children younger than 60 months were included from the 2005-2014 National Health and Nutrition Examination Survey (NHANES). We compared two birth cohorts with regard to their associations between WIC participation and being ever-breastfed and breastfed at 6 months. We estimated the average effect of the treatment for the treated to assess the causal effect of WIC participation on breastfeeding based on propensity score matching. The results showed that WIC-eligible participating children born between 2000 and 2008 were significantly less likely than WIC-eligible nonparticipating children to ever receive breastfeeding (p \u3c 0.05) or to be breastfed at 6 months (p \u3c 0.05). Among children born between 2009 and 2014, WIC-eligible participating children were no longer less likely to ever receive breastfeeding compared to WIC-eligible nonparticipating children; the gap remained in breastfeeding at 6-months (p \u3c 0.05). The disparities in prevalence of ever breastfed between WIC-eligible participants and nonparticipants have been eliminated since the 2009 WIC revision. More efforts are needed to improve breastfeeding persistence among WIC-participating mother-infant dyads

Impact of Irrigation Strategies on Tomato Root Distribution and Rhizosphere Processes in an Organic System.

Root exploitation of soil heterogeneity and microbially mediated rhizosphere nutrient transformations play critical roles in plant resource uptake. However, how these processes change under water-saving irrigation technologies remains unclear, especially for organic systems where crops rely on soil ecological processes for plant nutrition and productivity. We conducted a field experiment and examined how water-saving subsurface drip irrigation (SDI) and concentrated organic fertilizer application altered root traits and rhizosphere processes compared to traditional furrow irrigation (FI) in an organic tomato system. We measured root distribution and morphology, the activities of C-, N-, and P-cycling enzymes in the rhizosphere, the abundance of rhizosphere microbial N-cycling genes, and root mycorrhizal colonization rate under two irrigation strategies. Tomato plants produced shorter and finer root systems with higher densities of roots around the drip line, lower activities of soil C-degrading enzymes, and shifts in the abundance of microbial N-cycling genes and mycorrhizal colonization rates in the rhizosphere of SDI plants compared to FI. SDI led to 66.4% higher irrigation water productivity than FI, but it also led to excessive vegetative growth and 28.3% lower tomato yield than FI. Our results suggest that roots and root-microbe interactions have a high potential for coordinated adaptation to water and nutrient spatial patterns to facilitate resource uptake under SDI. However, mismatches between plant needs and resource availability remain, highlighting the importance of assessing temporal dynamics of root-soil-microbe interactions to maximize their resource-mining potential for innovative irrigation systems